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KMID : 0358420020450040659
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Korean Journal of Obstetrics and Gynecology
2002 Volume.45 No. 4 p.659 ~ p.665
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The clinical significance of Interleukin-6 mRNA expression in cervical intraepithelial neoplasia and cervical cancer
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Moon Hye-Sung
Choi Eun-Ah
Chung Hye-Won
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Abstract
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Objectives : Interleukin-6 is a pleiotrophic cytokine that is not only a mediator in major immunologic reactions but also a growth factor of keratinocytes. We studied IL-6 mRNA expression in cervical cancer, CIN and normal cervix. And we questioned whether its expression is related to cervical carcinogenesis and other prognostic factors.
Methods: The normal cervical and cervical cancer tissues were taken from healthy women (n=16), and the patients with CIN (n=36) and cervical cancer (n=36). The IL-6 mRNA expression was examined by quantitative competitive PCR after polymerase chain reaction amplification of reverse transcriptase copies of RNA transcripts (RT-PCR).
Results: There was no statistically different among cervical cancer, CIN and normal cervix (p>0.05). The IL-6 mRNA expression was not different according to the grades of CIN. Its expression was not correlated with the stage of cervical cancer, size of tumor, and histopathologic type (p>0.05).
Conclusion: These results suggested that IL-6 mRNA expression might not be associated with the cervical carcinogenesis and prognosis of cervical cancer.
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KEYWORD
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IL-6, Cervical cancer, CIN, Carcinogenesis
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